Della Grigsby began her musical studies at age 5, playing piano. At age 9, she began to play the cello. Della studied with renowned classical teachers. She was a student of Johanna deKeyser, a Tchaikovsky Competition Winner, and Gabor Rejto, a protégé of Pablo Casals. 

She has played in the following symphonies: 

• Long Beach Symphony Orchestra
• Santa Barbara Symphony Orchestra
• Clear Lake Symphony
• Symphonica de Loja (Ecuador National Symphony)
• Northwest Florida Symphony Orchestra

She's even taught a Master's Class at the Festival Internacional de Musica, Loja, Ecuador. 

Della has always been fascinated by rhythm. Throughout her classical career she has experimented with various genres on the side.

• Rock & Roll – in LA she played in Wendall Nightfall and first electrified her cello
• Jazz – in Boston she studied at the Berklee School of Music and played in the Dues Band
• Country & Western – in Houston she added C&W tunes to her repertoire
• New Age Music – in Boston she collaborated with composers and musicians and played a concert in the Great Pyramid of Giza, Egypt
• Celtic Music – in Houston she played with the Astronaut Band, Astronique and performed at the International Celtic Music Festival, Lorient, France
• Latin – while playing in the Symphonica de Loja, she performed traditional salsa/Latin music